Levitra is a drug for the treatment of erectile dysfunction. Levitra restores impaired erectile function and ensures a normal response to sexual stimulation.
The physiological mechanism of erection is the relaxation of the smooth muscles of the cavernous bodies and arterioles. Vardenafil blocks specific phosphodiesterase type 5, which enhances the effect of endogenous nitric oxide, which is released during sexual stimulation from the nerve endings of the corpora cavernosa and increases blood flow to the penis.
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Indications and dosage
Used to treat erectile dysfunction (inability to achieve/maintain an erection for sexual intercourse).
Levitra is used orally, administration does not depend on food intake. The recommended starting dose is 10 mg. The tablets are taken within 25-60 minutes. before the start of sexual intercourse (can also be used 4-5 hours before sexual activity). Levitra works after adequate sexual stimulation.
Depending on the effectiveness and tolerability of the drug, the dose may be increased to 20 mg or decreased to 5 mg. The maximum recommended dose is 20 mg, no more than 1 time per day.
For men over 65 years of age, it is recommended to consider the rationality of prescribing an initial dose of 5 mg.
For patients with mild hepatic impairment, there is no need to adjust the dose. For patients with moderate liver failure, an initial dose of 5 mg per day is recommended. In the future, the dose can be increased to 10 mg (taking into account the effectiveness and tolerability). In severe liver failure, the pharmacokinetics of vardenafil have not been studied.
There is no need for dose adjustment in patients with renal impairment. In patients on dialysis, the pharmacokinetics of the active substance of the drug has not been studied.
Overdose
Doses up to 80 mg are tolerated without serious side effects. Possible back pain (muscle or neurological toxicity has not been established). If necessary, provide symptomatic and supportive therapy. The use of dialysis does not increase the clearance of vardenafil.
Side effects
As a rule, Levitra is well tolerated.
Mild or moderate transient side effects are possible:
- Headache
- Dizziness
- Tides
- Nasal congestion
- Nausea
- Dyspepsia
- Rarely and very rarely:
- Drowsiness
- Watery eyes
- Arterial hypertension
- Arterial hypotension
- Orthostatic hypotension
- Dyspnea
- Nose bleed
- Abnormalities in liver function tests
- Facial swelling
- Photosensitivity reaction
- Backache
- Myalgia
- Increased level of creatinine phosphokinase in the blood
- Sense of anxiety
- Fainting
- Convulsions
- Transient general amnesia
- Increased intraocular pressure
- Angina pectoris
- Myocardial ischemia
- Laryngeal edema
- Muscle stiffness
- Priapism
- Strengthening erection
Contraindications include individual sensitivity to Levitra components, simultaneous intake of nitrates or any NO donors, and simultaneous use of vardenafil with HIV protease inhibitors (indinavir and ritonavir).
The drug is not intended for women.
Levitra should be prescribed with caution to men with anatomical deformation of the penis; with diseases contributing to the development of priapism.
Combination with other drugs
Before you start taking the drug, you must obtain information about other medications.
Some features of taking Levitra with other medications:
No thorough studies have been conducted on the compatibility of vardenafil and nitrates; therefore, taking Levitra and its analogues with nitrates is prohibited.
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